Soluble hemostatic gauze tseem ceeb heev hauv kev phais niaj hnub no.Qhov hnav khaub ncaws no muaj cov khoom tshwj xeeb nanomaterials thiab hemostatic agents. Cov no pab kom tsis txhob los ntshav sai thiab kho qhov txhab sai. Hauv kev phais, soluble hemostatic gauzetxo cov kua dej thiab los ntshav tom qab ua haujlwm. Cov kws phais siv cov khaub ncaws no vim nws muaj kev nyab xeeb thiab ua haujlwm zoo hauv cov kev phais nyuaj.
Ntsiab Cai
Soluble hemostatic gauzepab nres los ntshav sai. Nws hloov mus rau hauv gel uas npog qhov txhab. Cov gel no pab cov ntshav txhaws thiab kaw qhov txhab.
Chitosan yog ib feem tseem ceeb ntawm cov khaub ncaws no. Nws nqus tau cov ntshav zoo thiab pab qhov txhab mob sai dua. Chitosan zom ib txwm nyob hauv lub cev.
Cov kev tshawb fawb soj ntsuam hais tias soluble hemostatic gauze txo cov kua dej tom qab kev phais. Qhov no pab cov neeg mob zoo dua thiab kho sai dua.
Yuav Ua Li Cas Soluble Hemostatic Gauze Ua Haujlwm
Mechanism ntawm Hemostasis
Soluble hemostatic gauze nres los ntshav nrog ib txoj kev tshwj xeeb. Thaum nws kov lub qhov txhab los ntshav, nws yuav siv dej los ntawm cov ntshav thiab kua dej. Qhov no ua rau kev hnav khaub ncaws hloov mus ua ib qho gel.Cov gel ua rau qhov chaw nyob hauv qhov txhab thiab npog cov hlab ntsha me. Platelets lo rau ntawm gel, thiab cov qe ntshav liab tuaj ua ke sai. Ib qho ntshav txhaws thiab txuas rau lub qhov txhab, txwv tsis pub los ntshav hauv vib nas this. Cov gel kuj lo rau cov ntaub so ntswg nyob ze, yog li nws nyob twj ywm txawm tias tus neeg mob txav los yog los ntshav muaj zog.
|
Kauj ruam |
Kev piav qhia |
|---|---|
|
1 |
Kev hnav khaub ncaws yuav siv dej thiab hloov mus rau hauv gel. |
|
2 |
Platelets lo rau ntawm gel. |
|
3 |
Cov qe ntshav liab sib sau ua ke thiab ua kom khov. |
|
4 |
Cov hlab ntsha thaiv cov hlab ntsha me. |
|
5 |
Ntshav nres sai. |
Cov khoom sib xyaw thiab nqus
Soluble hemostatic gauze siv cov ntaub ntawv tshwj xeeb los pab nqus ntshav thiab kho qhov txhab. Ntau cov khaub ncaws siv chitosan, uas yog ib qho ntuj tsim polysaccharide. Chitosan hnav khaub ncaws lo zoo thiab tua kab mob. Chitosan nqus cov ntshav thiab pab ua kom cov gel kom tsis txhob los ntshav sai. Nws kuj lov nyob rau hauv lub cev rauua glucosamine thiab N-acetyl glucosamine, uas muaj kev nyab xeeb thiab pab kho.
Qee qhov hnav khaub ncaws siv kaolin, uashloov mus rau clotting factor XIIthiab pab cov hlab ntsha sai dua. Paj rwb yog lwm yam khoom siv, tab sis chitosan hnav khaub ncaws ua haujlwm zoo dua vim tias lawv nqus cov ntshav ntau dua thiab tsis txhob los ntshav sai.
Surgiclean® Absorbable Hemostatic Hnav khaub ncawssiv regenerated cellulose. Cov khoom no tawg mus rau hauv qabzib thiab cellobiose hauv 7 mus rau 28 hnub. Kev hnav khaub ncaws tsis muaj dab tsi tom qab, yog li cov neeg mob tsis tas yuav muaj lwm qhov kev phais kom tshem tawm. Qhov muag muag ua rau kev hnav khaub ncaws zoo thiab yooj yim siv hauv ntau qhov kev phais.
Ua ntej hauv Hemostatic Dressings
Evolution ntawm Hemostatic Materials
Kev hnav khaub ncaws hemostatic tau hloov pauv ntau hauv nees nkaum xyoo. Thaum xub thawj, tib neeg siv paj rwb thiab gelatin sponges. Cov no tuaj yeem nres los ntshav tab sis qeeb thiab tsis tawg hauv lub cev. Tam sim no, cov kws tshawb fawb siv cov ntaub ntawv tshiab los ua kom cov ntshav tswj tau zoo dua thiab zoo dua.
Polysaccharide hemostatic cov ntaub ntawv pab qhov txhab kho sai.
Bio-inspired adhesive catechol-conjugated chitosan sticks zoo rau cov ntaub so ntswg.
Mesoporous silica thiab bioactive tsom iav pab kom tsis txhob los ntshav.
Tsawg invasive hemostatic biomaterials ua rau mob tsawg.
Chitosan- cov ntaub ntawv raws li ua haujlwm rau ntau hom qhov txhab.
Plasma technology ua rau cov neeg ua haujlwm hemostatic ua haujlwm zoo dua.
Gelatin-cov tshuaj microbial transglutaminase sib xyaw muab cov kev xaiv tshiab rau kev txwv tsis pub los ntshav.
Cov kws tshawb fawb tam sim no sim txoj hauv kev tshiab los tsim cov ntaub ntawv. Lawv xav ua kom cov khaub ncaws ua haujlwm zoo dua thiab nrawm dua. Lawv kuj xav siv lawv nyob rau ntau qhov chaw.Los ntawm kev hloov cov hom thiab tus nqi ntawm cov ntaub ntawv hemostatic, cov kws tshawb fawb pab cov khoom no tso tseg cov ntshav sai thiab nyab xeeb.
Kev tsim kho tshiab hauv Soluble Gauze
Niaj hnub nimno hnav khaub ncaws hemostatic siv cov khoom tshwj xeeb xws li chitosan. Chitosan nqus cov ntshav, ua cov gel, thiab pab qhov txhab zoo. Qee qhov hnav khaub ncaws tshiab siv nanotechnology los ua kom cov hlab ntsha sai dua thiab tua cov kab mob. Lwm tus siv tus kheej- nthuav ua npuas ncauj los ua qhov txhab thiab nres hauv cov ntshav.
|
Hom khaub ncaws |
Ntshav poob |
Hemostatic muaj peev xwm |
Biodegradability |
Cov ntaub so ntswg Regeneration |
Daim tawv nqaij Adhesion |
|---|---|---|---|---|---|
|
Chitosan CS-40 |
Tsawg dua |
Zoo dua |
Zoo heev |
Zoo tshaj |
Tsawg kawg |
|
Gelatin daim txhuam cev |
Ntau |
Txuj |
Nruab nrab |
Txuj |
Ntau |
Biodegradable hemostats yaj tawm hauv lub cev, yog li kws kho mob tsis tas yuav coj lawv tawm. Ntse hemostats tuaj yeem muab tshuaj los pab kho thiab txo qis kev pheej hmoo kis mob. Ntau cov khoom lag luam hemostatic, zoo li Surgiclean, muaj daim ntawv pov thawj tseem ceeb. ISO 13485 qhia tias cov khoom yog tsim los ntawm cov khoom zoo. CE cim txhais tau tias nws ua tau raws li European kev nyab xeeb thiab kev noj qab haus huv cov cai. Cov khoom no ua rau kev hnav khaub ncaws hemostatic muaj kev nyab xeeb, mos, thiab yooj yim rau cov neeg mob.
Kev tshawb fawb soj ntsuam ntawm Soluble Hemostatic Gauze
Kev ua tau zoo thiab tus nqi ua tau zoo
Cov kev tshawb fawb soj ntsuam pom tau hais tias soluble hemostatic gauze pab tswj los ntshav. Cov kws tshawb fawb piv cov ntaub qhwv no rau kev hnav khaub ncaws tsis tu ncua hauv kev phais. Lawv siv cov kev sim tshwj xeeb hu ua randomized controlled trials. Cov kws phais mob ntsuas ntshav poob thaum phais thiab kua dej tom qab phais. Cov lej no pab lawv pom tias cov ntaub qhwv ntsej ua haujlwm zoo npaum li cas.
Ntau cov kev tshawb fawb saib cov kev phais nyuaj xws li mandibular angle osectomy. Hauv ib txoj kev tshawb fawb, cov tib neeg siv cov ntaub soluble hemostatic gauze poob ntau cov ntshav thaum phais dua li pab pawg tswj. Rau lwm qhov kev phais, pab pawg kawm kuj muaj ntshav ntau dua. Tab sis tom qab kev phais, pab pawg tshawb fawb tau poob dej tsawg. Qhov no txhais tau hais tias kev hnav khaub ncaws pab tiv thaiv kom tsis txhob muaj dej tom qab phais.
Cov kws tshawb fawb tsis pom qhov sib txawv loj hauv lub sijhawm phais lossis dej poob tom qab 24 teev. Muaj kev sib txuas zoo ntawm tag nrho cov kua dej poob thiab cov dej poob hauv 24 teev. Qhov no qhia tau hais tias kws kho mob yuav tsum tau saib cov lej no ze. Kev hnav khaub ncaws zoo npaum li cas nyob ntawm qhov kev phais thiab qhov tshwm sim los ntshav ntau npaum li cas. Cov kws phais mob pheej sim cov kev hnav khaub ncaws no hauv ntau qhov kev phais.
Cov kev tshawb pom tseem ceeb los ntawm Randomized Controlled Trials
Cov kws phais tau pom cov kua dej tsawg dua tom qab phais hauv pab pawg kawm.
Lub sijhawm phais thiab cov kua dej poob tom qab kev phais yog tib yam.
Kev hnav khaub ncaws pab txo qis dej tom qab kev phais.
Qee qhov kev phais tseem muaj ntshav ntau dua, yog li xav tau kev tshawb fawb ntxiv.
Hnav khaub ncaws zoo li Surgiclean ua haujlwm zoo hauv ntau qhov kev phais.
|
Hom Kev phais |
Intraoperative ntshav poob |
Postoperative Drainage Volume |
Lub sijhawm ua haujlwm |
Hemostatic Peev Xwm |
|---|---|---|---|---|
|
Mandibular Angle Ostectomy |
Siab dua |
Tsawg dua |
Tsis txawv |
Muaj zog |
|
Mandibular Angle-Lub cev-Chin Curved Ostectomy |
Siab dua |
Tsis txawv |
Tsis txawv |
ntseeg tau |
Kev nyab xeeb thiab kho qhov txhab
Kev nyab xeeb thiab kev kho mob yog qhov tseem ceeb heev thaum siv soluble hemostatic gauze. Cov kev tshawb fawb pom tias cov hnav khaub ncaws no pab cov neeg mob kho sai thiab zoo dua. Chitosan hnav khaub ncaws tsau cov ntshav sai sai thiab ua cov gel. Cov gel no npog lub qhov txhab thiab pab nws zoo.
Soluble hemostatic gauze melts dhau sijhawm. Cov neeg mob tsis xav tau kev phais ntxiv kom tshem nws tawm. Qhov no ua rau cov neeg mob yooj yim dua thiab txo qis kev pheej hmoo kis mob. Cov khoom xws li Bioviva thiab SafeGauze HemoStat siv cellulose los ua gel. Cov gel ua rau lub qhov txhab thiab nyob hauv qhov chaw. Kev hnav khaub ncaws maj mam ploj mus, yog li tsis tshua muaj mob thiab muaj teeb meem tsawg.
Cov kws tshawb fawb hais tias chitosan hnav khaub ncaws ua kom ntshav ntau thiab pab qhov txhab zoo. Kev hnav khaub ncaws tiv thaiv lub qhov txhab ntev txog 24 teev. Nws zoo nkaus li mos thiab yooj yim rau siv. Cov kev sim tshuaj ntsuam xyuas pom tias hnav khaub ncaws txo qis qhov muaj feem ntawm cov pob txha qhuav thiab lwm yam teeb meem tom qab kev phais.
Kev nplij siab ntawm tus neeg mob thiab tsis muaj -Cov txiaj ntsig tshem tawm
Kev hnav khaub ncaws hloov mus rau hauv gel thiab seals qhov txhab.
Cov neeg mob hnov mob tsawg dua vim qhov hnav khaub ncaws melts.
Tsis tas yuav tshem tawm cov hnav khaub ncaws txhais tau tias tsawg dua mus ntsib kws kho mob.
Kev kis kab mob thiab teeb meem tshwm sim tsawg dua.
Chitosan hnav khaub ncaws ua haujlwm zoo thiab pab cov ntaub so ntswg loj tuaj.
|
Hom khaub ncaws |
Kev nplij siab tus neeg mob |
Xav tau kev tshem tawm |
Kev phom sij |
Kev kho mob |
|---|---|---|---|---|
|
Soluble Hemostatic Gauze |
Siab |
Tsis muaj |
Tsawg |
Ceev ceev |
|
Standard Gauze |
Nruab nrab |
Yuav tsum tau |
Siab dua |
qeeb |
Cov kev tshawb fawb soj ntsuam kuaj xyuas seb yuav ua li cas zoo thiab muaj kev nyab xeeb npaum li cas ntawm cov kab mob hemostatic gauze nyob rau hauv kev phais. Cov kws tshawb fawb siv cov kev ntsuam xyuas tshwj xeeb los sib piv cov hnav khaub ncaws thiab xyuas cov khoom xws li cov ntshav poob, cov kua dej poob, thiab cov ntshav nres sai npaum li cas. Chitosan hnav khaub ncaws qhia tau hais tias muaj zog thiab pab kom tsis txhob los ntshav hauv ntau qhov kev phais.
Cov ntawv thov hauv Kev Kho Mob thiab Kev Kho Mob
Kev siv phais mob
Cov kws kho mob siv soluble hemostatic gauze hauv ntau qhov kev phais. Qhov kev hnav khaub ncaws no pab kom tsis txhob los ntshav hauv kev ua haujlwm sib txawv. Cov kws phais neeg nyiam nws vim nws ua haujlwm nrawm thiab yooj yim siv. Cov lus hauv qab no teev qee qhov kev phais uas siv cov hnav khaub ncaws no:
|
Hom txheej txheem phais |
Kev piav qhia |
|---|---|
|
Kev phais mob plawv |
Siv nyob rau hauv lub plawv bypass thiab valve phais kom txhob los ntshav. |
|
Kev phais mob siab |
Pab kom tsis txhob los ntshav thaum lub siab ua haujlwm nrog kev pheej hmoo siab. |
|
Kev phais General |
Siv nyob rau hauv appendix thiab plab phais los tswj los ntshav. |
Cov kws phais kuj siv qhov hnav khaub ncaws no hauv lub mis, hernia, thiab kev phais poj niam. Cov hnav khaub ncaws mos haum rau qhov txhab ntawm ntau cov duab. Chitosan tseem ceeb hauv cov kev phais no. Nws nqus cov ntshav, ua cov gel, thiab pab qhov txhab zoo. Kev hnav khaub ncaws tuaj yeem txiav kom haum, yog li nws ua haujlwm rau ntau hom kev phais.
Emergency and Trauma Care
Thaum muaj xwm txheej ceev, hnav khaub ncaws hemostatic pab cawm neeg txoj sia. Cov kws kho mob siv soluble hemostatic gauze kom tsis txhob los ntshav sai ntawm qhov xwm txheej tshwm sim. Cov kev tshawb fawb qhia tias Combat Gauze, nrog chitosan, nres los ntshav hauv89% ntawm cov neeg mob. Hauv lwm txoj kev tshawb fawb, 73% ntawm cov tib neeg tau los ntshav nres, thiab 20% tau los ntshav tsawg dua tom qab siv cov khaub ncaws no. Cov kev ntsuam xyuas tsiaj pom tias cov ntshav poob tsawg dua thiab cov kua dej tsawg dua uas xav tau nrog chitosan hnav khaub ncaws ntau dua li cov ntaub qhwv li niaj zaus.
Chitosan ua haujlwm zoo hauv kev phais, tab sis muaj qee qhov teeb meem. Kev hnav khaub ncaws tuaj yeem ua rau kub hnyiab yog tias siv ntau dhau vim nws tau kub. Granular agents tuaj yeem siv rau hauv qhov chaw tawv. Qee qhov hnav khaub ncaws yuav tsum tau muab tshem tawm ua ntej kev phais tuaj yeem mus ntxiv. Txawm li cas los xij, cov khaub ncaws no yooj yim siv thiab ua haujlwm zoo hauv kev phais thiab thaum muaj xwm txheej ceev.
Yav tom ntej ntawm Hemostatic Solutions
Kev tshawb fawb tsis tu ncua
Cov kws tshawb fawb tab tom ua haujlwm los ua kom cov dej soluble hemostatic gauze zoo dua. Lawv xav hnav khaub ncaws uas tuaj yeem tua cov kab mob thiab pab qhov txhab zoo. Qee qhov hnav khaub ncaws kuj tuaj yeem muab tshuaj thiab pab cov ntaub so ntswg tshiab. Ntau tus kws tshawb fawb sim ua cov khaub ncaws uas haum rau txhua tus neeg mob cov kev xav tau. Qee pawg sib xyaw cov ntaub soluble hemostatic nrog lwm cov cuab yeej kho mob kom tau txais txiaj ntsig zoo dua. Cov tuam txhab tam sim no siv eco- cov ntaub ntawv tus phooj ywg thiab biodegradable los pab lub ntiaj teb.
Chitosan yog ib qho tseem ceeb vim nws tso tseg cov ntshav thiab pab qhov txhab zoo. Cov kev tshawb fawb tshiab sim chitosan nrog cov tshuaj tua kab mob. Qhov no ua rau lub qhov txhab kom tsis txhob kis kab mob. Qee qhov haujlwm sib xyaw chitosan nrog lwm cov ntaub ntawv kom tau txais txiaj ntsig ntau dua. Cov kws tshawb fawb kuj xav ua kom chitosan hnav khaub ncaws yooj yim dua thiab pheej yig dua. Lawv kawm txog li cas chitosan ua haujlwm nrog ntshav kom tsis txhob los ntshav sai.
|
Tswv yim |
Kev piav qhia |
|---|---|
|
Antibacterial Properties |
Chitosan thiab lwm yam tshuaj tua kab mob thiab ua kom qhov txhab huv si. |
|
Multifunctional Structures |
Kev hnav khaub ncaws nrog chitosan tuaj yeem txo qhov mob, tiv thaiv kab mob, thiab pab cov cell loj hlob. |
|
Optimization ntawm Synthesis |
Pab pawg sim ua chitosan hnav khaub ncaws sai dua thiab pheej yig dua los tsim. |
|
Nkag siab Mechanisms |
Cov kws tshawb fawb kawm paub yuav ua li cas chitosan tso tseg los ntshav kom tau txais txiaj ntsig zoo dua. |
Nthuav kev siv tshuaj kho mob
Cov kws kho mob tam sim no siv soluble hemostatic gauze hauv ntau qhov kev phais. Qhov kev hnav khaub ncaws no pab kom tsis txhob los ntshav hauv pob txha, capillary, arterioles, thiab venous qhov txhab. Chitosan ua haujlwm zoo hauv plawv, siab, thiab kev phais dav dav. Cov kua qaub los ntawm chitosan kuj tua cov kab mob thiab ua kom qhov txhab zoo.
Cov tsev kho mob tso siab rau cov khaub ncaws no vim lawv ua raws li kev cai nruj nruj. FDA xav pab tshiab absorbable hemostats ncav cuag cov neeg mob sai dua. Cov tsev kho mob yuav tsum qhia cov khaub ncaws tshiab ua haujlwm nrog rau cov qub hauv kev sim. Cov kev cob qhia qhia cov kws phais yuav siv chitosan hnav khaub ncaws zoo li cas.
Soluble hemostatic gauze pab kom cov neeg mob muaj kev nyab xeeb. Nws tso tseg los ntshav sai thiab yaj ntawm nws tus kheej. Cov neeg mob kho sai dua thiab muaj teeb meem tsawg dua. Kev hnav khaub ncaws ntse tshiab thiab cov txheej txheem tshwj xeeb yuav pab tau ntau dua. Cov kws tshawb fawb xav tias cov kev daws teeb meem no yuav raug siv ntau dua li kev siv tshuab zoo dua.